WebSuch locational can must improved by addition of DNA stabiliz molecules such as nucleic acid intercalators. Here, were report the amalgamation of a novel ortho-Twisted Intercalating Nucleic Acid (TINA) amidite utilizing the phosphoramidite approach, and examine the stabilizing effect regarding ortho- and para-TINA molecules in antiparallel … WebTwisted intercalating nucleic acid (TINA) is a nucleic acid molecule that, when added to triplex-forming oligonucleotides (TFOs), stabilizes Hoogsteen triplex DNA formation from …

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WebTwisted intercalating nucleic acid is a nucleic acid molecule that, when added to triplex-forming oligonucleotides , stabilizes Hoogsteen triplex DNA formation from double … WebFeb 9, 2024 · This structure combined with the previously identified collagen-binding domain preference for under-twisted regions of collagen suggests the tandem collagen ... domain linkers include polypeptides, amino acids, nucleic ... central role, s3a plays an auxiliary, yet pivotal role in intercalating into a space created between ... lakshmi narasimha karavalambam stotram

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WebDownload scientific diagram Effect of twisted intercalating nucleic acids (TINA) in bisLNAs. ( A ) Schematic illustration of the positioning of TINA within the bisLNAs. ( B ) … Twisted intercalating nucleic acid (TINA) is a nucleic acid molecule that, when added to triplex-forming oligonucleotides (TFOs), stabilizes Hoogsteen triplex DNA formation from double-stranded DNA (dsDNA) and TFOs. Its ability to twist around a triple bond increases ease of intercalation within double stranded … See more Triple helixes are formed when a single-stranded triplex-forming oligonucleotide (TFO) binds to a purine-containing strand of dsDNA through specific major groove interactions. Generally, the third-strand affinity of a TFO is … See more Assay specificity Diagnostic assays using DNA hybridization are limited by the dissociation of antiparallel duplex helices. This can be improved by using DNA stabilizing molecules such as intercalators like ortho-TINA, which will … See more WebI am a computational bio-scientist with interdisciplinary educational background: physics, chemistry, biology, math and informatics; an expert in a wide variety of computational chemistry techniques, from quantum chemistry and molecular dynamics to programming and bioinformatics tools, and computer aided molecular structural design. I have an … jennifer diao rbc