WebAnother putative receptor is the chemokine receptor type 4 (CXCR4), through which TFF3 might mediate cell migration via an ERK1/2-independent signaling pathway. (39) TFF3 is … Web26 Jun 2012 · TFF3 discriminates between more or less metastatic cells; higher expression was associated with propensity to invade the lymphovasculature or the axilla. ... 24 Rickman DS, Chen YB, Banerjee S et al. ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression. Neoplasia 12(12),1031–1040 (2010 ...
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Web23 Sep 2013 · The molecular mechanisms of Tff3 action are still unclear. Though no binding molecule has been identified with the classical characteristics of a receptor , we speculate that Tff3 may act through a receptor-mediated way. Additional studies are required to identify putative Tff3 receptor in the future. Web25 Jun 2024 · Trefoil factor family peptides (TFF1, TFF2, TFF3) are typically co-secreted together with mucins. Tff1 represents a gastric tumor suppressor gene in mice. TFFs are also synthesized in minute amounts in the immune and central nervous systems. In mucous epithelia, they support rapid repair by enhancing cell migration (“restitution”) … is link market services down
Table 2. Receptor-ligand binding affinities and IC50 values for...
Web30 Jun 2015 · Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5), also known as GPR49, belongs to the G-protein-coupled receptor family of proteins and is a target of Wnt signaling (Pinson et al. 2000; Van der Flier et al. 2007; Haegebarth & Clevers 2009). It has been recently identified as a novel stem cell marker of IESCs (Umar 2010). Web1 Dec 2024 · Trefoil factor 3 (TFF3) is a small molecule polypeptide that is mainly secreted by intestinal mucus cells, and it is distributed widely in normal human tissues [1, 2].TFF3 consists of 59 amino acids and contains a characteristic three-looped structure, as shown in Fig. 1.The trefoil domain structure is composed of three intramolecular disulfide bonds … WebDownload Table Receptor-ligand binding affinities and IC50 values for epithelial cells (n = 6). from publication: Kinetic Characterization of an Intestinal Trefoil Factor Receptor To determine ... kharla property holdings ltd