High-mannose oligosaccharide
WebOct 12, 2015 · Previous studies have shown that these receptors bind the outer trimannose branch Man{alpha}1-3[Man{alpha}1-6]Man{alpha} present in high mannose structures. Although the trimannoside binds to DC-SIGN or DC-SIGNR more strongly than mannose, additional affinity enhancements are observed in the presence of one or more … WebA high-mannose oligosaccharide is attached to asparagine-117, and fucosylated complexes are attached to asparagines-184 and-448. Endogenous t-PA is produced as a one-chain …
High-mannose oligosaccharide
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WebJun 1, 2024 · This high-mannose-type glycan is subsequently trimmed by the specific actions of glucosidases and mannosidases, giving rise to various processing …
WebThe high-energy collision-induced dissociation spectra of a series of linear and branched synthetic mannosyl oligosaccharides that contain 6-phosphate substituents on either or both non-reducing terminal or penultimate residues have been studied. These phosphorylated structures were designed to mimic those of naturally derived N-glycans … WebJan 1, 2024 · The ability of the mannose receptor to facilitate uptake of glycoproteins bearing high-mannose oligosaccharides is used to target therapeutic glycoproteins to macrophages, particularly in the treatment of lysosomal storage diseases ( 8, 9 ). The mannose receptor also functions as part of the innate immune system.
WebApr 11, 2024 · High-fat diets (HFD) can promote the development of hepatic steatosis by altering the structure and composition of gut flora. In this study, the potential therapeutic mechanism of Lycium barbarum oligosaccharide (LBO) against hepatic steatosis was investigated by analyzing the changes in the intestinal flora and metabolites in mice. Mice … WebMar 1, 1996 · In addition, the distribution of oligosaccharide type(s) at these confirmed sites of N-linked glycosylation has been examined. ... 1993, 2275, and 2562) contain high mannose type units and two sites (at positions 179 and 1345) are linked to oligosaccharide units containing galactose in addition to mannose and glucosamine but no fucose and …
WebJul 20, 2024 · Trimming of high mannose residues on an ERAD substrate glycoprotein and the requirement of Man1A. ... in which Htm1-mediated mannose trimming from the oligosaccharide Man8GlcNAc2 to Man7GlcNAc2 is ...
WebJan 19, 2016 · Other studies show that high-mannose type oligosaccharides on an IgG increase its serum clearance ( Goetze et al. 2011; Alessandri et al. 2012 ). Significant research has evaluated the N-linked glycosylation of the Fc region of IgG type antibodies and antibody fragments. tax collector service centerWebJan 26, 2015 · Abstract Terminal "high-mannose oligosaccharides" are involved in a broad range of biological and pathological processes, from sperm-egg fusion to influenza and … tax collectors delray beachWebJun 1, 2000 · The following glycans were used as oligosaccharide standards: high-mannose MAN-9; hybrid HYBR; asialo-, galactosylated tetraantennary NA4; di-sialylated, galactosylated biantennary, core substituted with fucose A2F. All calibrants (1–5 pmol/µl) were dissolved in 0.1% trifluoroacetic acid (TFA) in ultrapure Milli-Q Plus water. 2,5-dihydroxy ... tax collector sebring flWebThis oligosaccharide modification is catalyzed by an oligosaccharyl transferase. The glucose-containing high-mannose type oligosaccharide transferred to nascent polypeptide chains is processed by glycosidases and glycosyltransferases in the ER or Golgi apparatus to complex type structures. the cheapest home insurance companyWebOligosaccharide ABSTRACT Molecular recognition of mannose-6-phosphate (M6P)-modified oligosaccharides by transmembrane M6P re-ceptors is a key signaling event in lysosomal protein trafficking in vivo. Access to M6P-containing high-mannose N-glycans is essential to achieving a thorough understanding of the M6P ligand–receptor recognition … tax collectors berks countyWebThis trimeric structure also seems suitable for detecting pathogens with high mannose density. The paper of Feinberg et al. mentions other examples of oligomeric lectins. A trimeric oligosaccharide ligand with appropriate linker length for the 40 Å distance between each binding site has been reported for Langerin, with 1,000-fold higher ... tax collectors bible timesWebPubMed tax collector seminole fl