Collagen and antiplatelet activity
WebThis study investigated whether paclitaxel exhibits antiplatelet activity in human platelets. Methods and results: Paclitaxel inhibited platelet aggregation induced by collagen but not that induced by thrombin, arachidonic acid, or U46619, suggesting that paclitaxel is more sensitive to the inhibition of collagen-induced platelet activation. WebSeveral unique technologies have been devised to assess platelet function by measuring platelet activation and aggregation in response to a variety of agonists (1). This review …
Collagen and antiplatelet activity
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WebNational Center for Biotechnology Information Blood platelet activation is involved not only in hemostasis, but also in the pathophysiology of various diseases. One such group of diseases is that of cardiovascular disorders: these are the leading cause of global mortality and have a substantial economic impact. Dysregulation of blood platelet … See more Nutraceuticals are used to supplement the diet with substances of natural origin that occur normally in food but in limited quantities, and which … See more Wang et al. (8) suggest that dietary supplements contain various pharmacologically active agents, which may affect not only blood platelet function, but also blood … See more Blood platelets play an important role in cardiovascular disorders, both in atherosclerosis and in the development of acute thrombotic events (6). Their significance in … See more Dietary supplements are a common component of the diet in various countries. Stanger et al. (55) recently noted that about half of the … See more
WebJan 14, 2004 · Salicylate does not affect COX-1 or COX-2 activity . ... The test is performed by combining 2 agonists in cartridge form: collagen/ADP and collagen/epinephrine. Closure time is the time required for platelets to effect full occlusion of an aperture cut into a membrane coated with the pair of agonists. ... Resistance to other antiplatelet drugs ...
WebAs shown in Figure 2, the combination of GBE50 and aspirin showed significant antiplatelet effects on AA, PAF, ADP and collagen induced platelet aggregation and the IC50 values were 0.067 mg/mL, 0.289 mg/mL, 1.474 mg/mL and 0.149 mg/mL, respectively, and thus, the combination exhibited superior antiplatelet effects than that of GBE50 or aspirin ... WebSep 26, 2024 · This activity reviews the indications, contraindications, action, adverse events, and other key elements of antiplatelet drugs essential to clinical practice. Objectives: Summarize the mechanisms of …
WebAntiplatelet Activity of Epigallocatechin Gallate Is Mediated by the Inhibition of PLCγ2 Phosphorylation, Elevation of PGD 2 Production, and Maintaining Calcium-ATPase Activity. ... catechin derived from green tea, were extensively investigated. EGCG inhibited arterial thrombus formation and U46619-, collagen-, and arachidonic acid ...
WebAt the same dose, ex vivo platelet aggregation induced by ADP, collagen, and AA was inhibited by l-NBP and the antithrombotic effects of the compound were also observed. Thus, NBP exerts oral anti-platelet and anti-thrombotic efficacy without perturbing systemic hemostasis in rats. l-NBP is more potent than d- and dl-NBP as antiplatelet agent. share google one storage with family memberWebJan 1, 2024 · Platelets trigger thrombus formation by activating exposed collagen at the site of blood vessel injury and subsequent aggregation, which leads to the formation of a … share google form responsesWebSep 1, 2013 · Antiplatelet activity of Phellinus baummii methanol extract is mediated by cyclic AMP elevation and inhibition of collagen-activated integrin-alpha(IIb) beta(3) and MAP kinase Phytother Res , 25 ( 2011 ) , pp. 1596 - 1603 share google formsWebTaken together, these results indicate that three of these six beta-carboline alkaloids can selectively affect collagen-induced platelet aggregation with different potencies; in particular, harmane and harmine were most potent, and their antiplatelet activities may be mediated by inhibiting PLCgamma2 and protein tyrosine phosphorylation with ... share google earth my placesWebJun 8, 2015 · Collagen, the most thrombogenic subendothelial matrix component, triggers directly the adhesion of platelets to the vessel wall via its interaction with the α2β1 integrin. This facilitates the activation of … share google form templateWebDec 4, 2010 · Examples of proteins that are affected by well-characterized gene defects in humans include α IIb β 3 (Glanzmann's thrombasthenia), GP Ib (Bernard-Soulier syndrome), VWF (von Willebrand's disease), and the collagen receptor, GP VI, among others. 5 Understanding platelet function at this level provides a framework for the development of ... share google drive without accountWebDec 1, 2008 · Request PDF Antiplatelet activity of β-carboline alkaloids from Perganum harmala: A possible mechanism through inhibiting PLCγ2 phosphorylation Beta-carboline alkaloids including harmalol ... share google forms results